Hollywood besties and frenemies [SLIDESHOW]

Alyssa Moody Contributor
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They may have started out as on-screen pals on the NBC series, Friends, but Jennifer Aniston and Courteney Cox quickly took their friendship off-set. The pair became inseparable, and were often spotted vacationing together or sharing meals in Hollywood.  Jen’s even godmother to Courtney’s daughter, Coco. After a close, long-standing friendship, US Weekly reported that the famous besties went their separate ways. So what pulled apart their seemingly unbreakable bond? According to the mag, a dispute arose between the two when Cox was spotted getting cozy with “Cougar Town” co-stars, Josh Hopkins and Brian Van Holt, even though her divorce from David Arquette isn’t final.

“Jen thinks Courtney is acting callous by running around with this guy but refusing to file divorce papers,” said a source. “Like she’s playing mind games with David.”

Whatever the reason, it’s always sad to see a close friendship end, especially since genuine relationships are a rarity in Hollywood. In honor of the duo’s recent split, take a look at other famous frenemies, as well as the pairs that just might stay best friends forever.